Clinical Trial

Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

Recruiting
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Summary
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2026-08 -> 2026-12 2026-05-07
minor Completion pushed: 2026-08 -> 2026-12 2026-05-07
Trial Details
NCT Number NCT07044596
Lead Sponsor University of Wisconsin, Madison
Collaborators: Neuraworx Medical Technologies
Conditions Mild Traumatic Brain Injury, Post Concussion Syndrome
Enrollment 55 participants
Start Date 2025-11-13
Primary Completion 2026-12 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-05-06