Three-Vessel Versus Unilateral Antegrade Cerebral Perfusion in Emergency Total Arch Replacement for Acute Type A Aortic Dissection

This single-centre retrospective observational cohort study describes the technical feasibility of direct three-vessel antegrade cerebral perfusion, designated modified antegrade cerebral perfusion (MACP), during emergency total arch replacement for acute type A aortic dissection. MACP delivers antegrade cerebral perfusion directly to the brachiocephalic, left common carotid, and left subclavian arteries. Outcomes are summarised descriptively and compared exploratorily with unilateral right axillary antegrade cerebral perfusion (uACP). Because perfusion strategy and treating surgeon were completely confounded, the comparative analyses are intended only to contextualise the technical experience and generate hypotheses.

NCT Number	NCT07043777
Lead Sponsor	China Medical University Hospital
Conditions	Acute Type A Aortic Dissection
Enrollment	201 participants
Start Date	2021-01-01
Primary Completion	2025-04-30 (estimated)
Study Completion	2025-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-01