Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens

The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017. The secondary aim is to compare metabolic risk factors, metabolic disturbances, and clinically relevant metabolic outcomes between the follow-up period and the baseline assessment. The exploratory goal is to examine the relationships between changes in risk factors and clinical outcomes in the participants. The study is planned to begin in May 2025 and will finalize the data collection for the entire population by June 2026. During this time, participants will be categorized based on CKM staging. The follow-up phase will continue until 2035.

NCT Number	NCT07043166
Lead Sponsor	Shanghai Changzheng Hospital
Conditions	Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension, Dyslipidemia, Thyroid Diseases, Bone Metabolism Disorder, Chronic Kidney Disease(CKD) +2 more
Enrollment	4,094 participants
Start Date	2025-07-01
Primary Completion	2035-05-30 (estimated)
Study Completion	2035-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-09-08