Natural History of Advanced Chronic Liver Diseases

This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.

NCT Number	NCT07042308
Lead Sponsor	Chinese University of Hong Kong
Conditions	Cirrhosis, Advanced Chronic Liver Disease
Enrollment	500 participants
Start Date	2024-09-25
Primary Completion	2035-12 (estimated)
Study Completion	2035-12 (estimated)
Updated on ClinicalTrials.gov	2025-06-29