No Reduction Compared to Closed Reduction for Distal Radius Fractures in Patients Over 65 or Older

DISCLOSE trial is a randomized controlled trial including 532 participants with low-energy distal radius fractures. The primary objective is to evaluate whether casting without prior closed reduction is equivalent to casting following closed reduction with respect to wrist-related pain and disability, as measured by the Patient-Rated Wrist Evaluation (PRWE) score at 12 months, in patients aged 65 years or older with a displaced distal radius fracture. * Primary endpoint will be PRWE at 12 months * Follow-up visits are scheduled at 3 and 12 months. 5-year follow-up will be considered as an exploratory endpoint

NCT Number	NCT07042139
Lead Sponsor	Tampere University Hospital Collaborators: Kuopio University Hospital, Viborg Regional Hospital, Karolinska University Hospital, Helsinki University Central Hospital, Tartu University Hospital, Pori Central Hospital, Oulu University Hospital
Conditions	Distal Radius Fracture, Casting, Closed Reduction
Enrollment	532 participants
Start Date	2025-08-01
Primary Completion	2029-07-01 (estimated)
Study Completion	2033-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-21