Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia

This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia. While methylene blue is commonly used for sentinel lymph node mapping, its potential systemic vasopressor effects remain unclear. To provide a comprehensive analysis, the study will compare patients receiving methylene blue with a control group of patients undergoing similar breast procedures without the use of any dye. Hemodynamic parameters such as blood pressure, heart rate, and oxygen saturation will be recorded and compared between the two groups to determine the specific impact of methylene blue on the incidence of intraoperative hypotension and the need for vasopressor support.

NCT Number	NCT07040540
Lead Sponsor	Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Conditions	Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue, Hemodynamic Stability, Intraoperative Hypotension
Enrollment	220 participants
Start Date	2025-07-01
Primary Completion	2025-11-01 (estimated)
Study Completion	2026-01-10 (estimated)
Updated on ClinicalTrials.gov	2026-04-30