Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

NCT Number	NCT07040163
Lead Sponsor	CAMC Health System Collaborators: Sarah & Pauline Maier Foundation, Inc., Radiological Society of North America, Society of Interventional Radiology Foundation
Conditions	Sedation, Interventional Radiology, Biopsy, Drainage Procedure
Enrollment	276 participants
Start Date	2025-03-07
Primary Completion	2026-02-13 (estimated)
Study Completion	2026-06 (estimated)
Updated on ClinicalTrials.gov	2026-02-23