A Multicenter, Prospective, Randomized, Controlled Clinical Study on the Effect of Hysteroscopic Uterine Septum Resection on the Natural Pregnancy Outcomes in Patients With Non-recurrent Spontaneous Abortion

The study aims to compare the effects of transcervical resection of septa (TCRS) and expectant management on the natural pregnancy outcomes of patients with septate uterus without recurrent abortion, also covering the treatment of other infertility factors in infertile patients who aim at natural conception. The research attempts to answer whether TCRS can improve the live birth rate, pregnancy rate and pregnancy outcomes for septate uterus patients planning natural pregnancy, so as to provide evidence-based medical evidence for the selection of clinical treatment methods for such patients.

NCT Number	NCT07039097
Lead Sponsor	The Third Xiangya Hospital of Central South University Collaborators: Obstetrics & Gynecology Hospital of Fudan University, Peking Union Medical College Hospital, Maternal and Child Health Hospital of Hubei Province, Beijing Tiantan Hospital, Anhui Provincial Hospital, Fu Xing Hospital, Capital Medical University, Tongji Hospital, The First People's Hospital of Yunnan, Women's Hospital School Of Medicine Zhejiang University, Southwest Hospital, China, The First Hospital of Jilin University, Tianjin Medical University General Hospital, Xijing Hospital, Shandong University, Guangzhou First People's Hospital, Gansu Provincial Maternal and Child Health Care Hospital
Conditions	Infertility and Miscarriage
Enrollment	418 participants
Start Date	2025-06-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2030-06-01 (estimated)
Updated on ClinicalTrials.gov	2025-06-26