Using a Speech-Generating Device to Support Communication in Rare Genetic Conditions

Individuals with rare genetic conditions may experience a delay or loss of developmental skills. Many have limited verbal speech. The aim of this clinical trial is to examine how well a speech-generating device supports the communication skills of participants with a rare genetic condition. The speech-generating device is a communication program loaded onto an iPad. This is a crossover trial, meaning that each participant will receive both the treatment (device) and a control (usual care; no device) phase. The order in which each participant receives the device versus the usual care (no device) will depend on which group the participant is assigned to. The changes in communication in each phase will then be compared. During the trial, participants can expect to complete a series of assessments and attend a total of 2 x 1-hour therapy session per week for 6 weeks.

NCT Number	NCT07039084
Lead Sponsor	Murdoch Childrens Research Institute
Conditions	Genetic Disease, Nonverbal Communication, Augmentative and Alternative Communication, Rare Genetic Disease, Rare Genetic Disorders
Enrollment	38 participants
Start Date	2025-11-03
Primary Completion	2027-05 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-26