Reducing the Resection Range After Neoadjuvant Therapy for Locally Advanced Upper Rectal and Rectosigmoid Junction Cancers

The goal of this clinical trial is to learn evaluate the safety and efficacy of reduced surgical resection margins in patients with local advanced upper rectal or rectosigmoid junction tumors who met the ycT≤3N0M0 regression following neoadjuvant therapy. The main questions it aims to answer are: Does reduced surgical resection margins (3 cm of distal margin and 5 cm of proximal margin) meet the radical resection criteria, including the rate of negative resection margin, the number of lymph node harvested? How is the surgical safety of reduced surgical resection, including the surgical duration , bleeding, recovery time and postoperative complications? Is reduced surgical margins resection (3 cm of distal margin and 5 cm of proximal margin) inferior to conventional surgical margins resection (5 cm of distal margin and 10 cm of proximal margin) in terms of oncology safety?

NCT Number	NCT07038122
Lead Sponsor	Sixth Affiliated Hospital, Sun Yat-sen University
Conditions	Locally Advanced Rectal Carcinoma
Enrollment	874 participants
Start Date	2025-07-01
Primary Completion	2027-06-20 (estimated)
Study Completion	2028-06-20 (estimated)
Updated on ClinicalTrials.gov	2025-12-18