Effect of Moringa Royal Jelly on the Nutritional Status and Cognitive Level of Adolescent Girls

The goal of this clinical trial is to learn whether a locally developed supplement called MRJ - a combination of Moringa oleifera (drumstick tree) extract and royal jelly - can improve the nutritional status and cognitive function of adolescent girls more effectively than standard iron and folic acid (IFA) tablets. The main questions it aims to answer are: Does MRJ supplementation lead to better improvements in nutrition (e.g., hemoglobin, body measurements)? Does MRJ supplementation enhance cognitive function compared to IFA tablets? Researchers will compare MRJ capsules to IFA tablets (the standard of care) among adolescent girls. Participants will: Take 2 MRJ capsules per week (intervention group) or 1 IFA tablet per week (control group) for 12 months Receive nutrition education via short TikTok-based videos Have their adherence monitored weekly by teachers and through WhatsApp photos Measurements will be taken at the start, 6 months, and 12 months, including: Height, weight, and mid-upper arm circumference (MUAC) Hemoglobin levels via finger-prick blood test Dietary intake using a 24-hour recall and food frequency questionnaire (FFQ) Cognitive function assessed with the Culture Fair Intelligence Test (CFIT) Participants are healthy junior and senior high school girls aged 10-18 years from Galesong Selatan, Takalar District, South Sulawesi, Indonesia. Potential side effects (e.g., nausea or stomach discomfort) will be monitored according to school health protocols. The findings may support the use of culturally appropriate, nutrient-rich interventions for improving adolescent girls' health and future well-being.

NCT Number	NCT07037498
Lead Sponsor	Hasanuddin University
Conditions	Undernutrition, Anemia, Stunting, Cognitive Function 1, Social
Enrollment	372 participants
Start Date	2025-02-10
Primary Completion	2025-06-10 (estimated)
Study Completion	2026-02-17 (estimated)
Updated on ClinicalTrials.gov	2025-08-08