Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus

This study aims to investigate the effects of intensive medical nutrition therapy on blood sugar control, systemic inflammation, and gut barrier function in adults with type 2 diabetes mellitus. In this randomized controlled trial, adults with type 2 diabetes mellitus will be assigned to either an intensive medical nutrition therapy group or a control group. The intensive medical nutrition therapy group will receive individualized nutrition therapy and weekly follow-ups for 12 weeks, while the control group will receive standard dietary counseling. The study will assess changes in glycemic control (HbA1c, fasting plasma glucose), inflammatory markers (TNF-α, IL-6), and intestinal permeability (ZO-1), as well as quality of life and self-care behaviors. The goal is to evaluate whether intensive medical nutrition therapy can improve metabolic outcomes and overall health in adults with type 2 diabetes mellitus.

NCT Number	NCT07037212
Lead Sponsor	Serap Balaban Barta
Conditions	Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation, Intestinal Permeability, Glycemic Control
Enrollment	40 participants
Start Date	2020-12-15
Primary Completion	2022-06-30 (estimated)
Study Completion	2022-10-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-27