Understanding Cycles to Improve Women's Health

Introduction: The C-HEALTH study investigates how environmental and socio-economic conditions affect women's menstrual cycles and reproductive health. Aim: To compare progesterone levels during the luteal phase among women from different socio-economic backgrounds living in rural and urban areas in southern France. Methods: This is a prospective observational study involving 320 healthy women of reproductive age. * Hormones (progesterone, estradiol) will be measured daily in saliva. * Inflammation (Protéine C Réactive: CRP) will be measured five times per cycle via blood drops. * Participants will wear a smart ring to monitor body temperature and activity. * Daily symptoms and lifestyle data will be collected. * Environmental exposures (pollution, stress, living conditions) will be assessed and linked to menstrual health outcomes.

NCT Number	NCT07037082
Lead Sponsor	University Hospital, Montpellier Collaborators: National Research Agency, France, Institut National de la Santé Et de la Recherche Médicale, France, Centre National de la Recherche Scientifique, France, Institute of Evolutionary Science of Montpellier, Université Montpellier
Conditions	Woman of Reproductive Age, Socioeconomic Factors
Enrollment	320 participants
Start Date	2025-09-01
Primary Completion	2029-07-01 (estimated)
Study Completion	2029-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-22