Clinical Trial

Aortic Dilatation Under 5 cm: Genetic Risk Mapping

Active, Not Recruiting

Record status

This record was last updated June 27, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.

Summary

This retrospective study investigates the prevalence of genetic mutations in patients with ascending aortic dilatation measuring between 4.0 and 5.0 cm-below the standard surgical threshold. Using Next Generation Sequencing (NGS), both syndromic and non-syndromic aortopathy gene panels were analyzed in 102 patients who had no history of aortic surgery, dissection, or known genetic disorders. Findings will be compared with population data to better understand genetic risk profiles in borderline aortic dilatation, potentially supporting earlier interventions based on genetic markers. The study was approved by the Samsun University Non-Interventional Clinical Research Ethics Committee (GOKAEK, 2025/9/2).

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2025-06-14.

Trial Details

NCT Number	NCT07034430
Lead Sponsor	Samsun University
Conditions	Ascending Aortic Dilatation, Aortic Aneurysm, Thoracic, Aortic Diseases
Enrollment	102 participants
Start Date	2024-01-01
Primary Completion	2026-01-01 (estimated)
Study Completion	2026-01-01 (estimated)
Updated on ClinicalTrials.gov	2025-06-27