Detecting Fatigue From Voice in Generalised Myasthenia Gravis

The goal of this observational study is to learn if computer analysis of voice recordings can detect a type of exhaustion called "central fatigue" in adults with generalised myasthenia gravis. The main questions it aims to answer are: 1. Can advanced voice analysis accurately tell when participants are experiencing deep exhaustion based on how they speak? 2. How easy and acceptable is voice-based fatigue monitoring for people with myasthenia gravis? Participants will: 1. Record themselves reading short passages and answering questions out loud twice daily (morning and evening), twice a week, for 4 weeks. 2. Answer brief questionnaires about their energy levels, mood, and myasthenia gravis symptoms during each session. 3. Use their own devices (computer, tablet, or smartphone) to complete all study activities online from home.

NCT Number	NCT07033559
Lead Sponsor	Thymia Limited Collaborators: UCB Pharma
Conditions	Myasthenia Gravis Generalised
Enrollment	240 participants
Start Date	2026-02
Primary Completion	2026-06 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2026-01-28