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A Trial Of Approach Bias Modification Training During Treatment For Cocaine Use Disorder

Study acronym: ABMCocaine
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Notable Start date: Dec 31, 2025 to Mar 31, 2026
    • Primary completion date: Jul 31, 2026 to Oct 31, 2026
    • Study completion date: Oct 1, 2026 to Oct 31, 2026
    v4
  2. Notable Start date: Jul 1, 2025 to Dec 31, 2025v3
  3. Notable Trial status: Not Yet Recruiting to Recruiting
    • Site details revised
    • Study title revised
    v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to investigate if the intervention "Approach Bias Modification" (ABM) can low cocaine craving in people with Cocaine Use Disorder (CUD). The main question this clinical trial aims to answer is how many days participants can be in abstinence from cocaine after 4 ABM sessions. ABM is a computerised training aiming to train the participants to: * avoid drug-related images by pushing a joystick which causes the image to disappear; * approach positive images by pulling a joystick which causes the image to expand. Researchers will compare participants treated with ABM to those who receive Treatment As Usual (TAU) condition to see if ABM training for CUD is more effective in increasing the number of abstinent days. * Participants will attend 1 ABM session per week for a total of 4 sessions, each lasting 15 minutes. * Both cocaine and non-cocaine positive images relative to the subjective values or interests (i.e. effects, sport, music, nature, work, etc.) are presented to the participant, in portrait or landscape orientation. * Participants are instructed to push the joystick if the image is portrait-oriented (cocaine-related images) or to pull the joystick if it is landscape-oriented (positive images). * At 1 and 3-month-follow up, participants will complete self-report questionnaires to measure abstinence days and describe the effect of ABM on cocaine use, dependence symptoms, and approach bias.
Trial Details
NCT Number NCT07033416
Lead Sponsor ASST Fatebenefratelli Sacco
Collaborators: Monash University
Conditions
(from sponsor)
Training for Cocaine Use Disorder
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov