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Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated Patients

Study acronym: CPM-ICU
StatusNot Yet Recruiting
PhaseNot applicable
Started
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Record status
This record was last updated June 29, 2025 (before its estimated September 30, 2025 completion). Its status may not reflect the trial's current state.

Record History

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  1. Secondary endpoints: 1 to 3
    • Study description expanded, about 356 words
    • Eligibility criteria expanded, about 1 word
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical trial aims to evaluate whether continuous passive motion (CPM) can prevent ankle joint contracture and muscle atrophy in critically ill patients receiving mechanical ventilation in the ICU. The study will also assess the feasibility and safety of implementing CPM therapy in this population. The primary objectives are: To determine whether CPM preserves ankle dorsiflexion range of motion during ICU immobilization. To assess whether ultrasound can detect changes in tibialis anterior muscle morphology in response to CPM. In this within-subject design, each participant will receive CPM therapy on one ankle while the contralateral ankle serves as the control. Outcomes related to joint mobility and muscle condition will be compared between the two sides. Participants will: Receive CPM treatment on one ankle for 30 minutes, twice daily, for up to 7 days or until ICU discharge. Undergo goniometric and ultrasound assessments at baseline and after the intervention. Continue to receive standard ICU care throughout the study period.
Trial Details
NCT Number NCT07032051
Lead Sponsor Shin Kong Wu Ho-Su Memorial Hospital
Conditions
(from sponsor)		 Ankle Contracture, Critically Ill Intensive Care Unit Patients, Muscle Atrophy
Related terms Muscular Atrophy
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov