Efficacy and Influencing Factors of ALIC-NAc Deep Brain Stimulation in Treatment-Refractory Obsessive-Compulsive Disorder

The goal of this clinical trial is to evaluate the efficacy and influencing factors of the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC-NAc) deep brain stimulation (DBS) in patients with treatment-refractory obsessive-compulsive disorder (OCD). The main questions it aims to answer is: Does the timing of DBS activation (at 1, 2, or 3 months post-surgery) affect the reduction rate in Y-BOCS scores? Researchers will compare three groups-DBS activated at 1, 2, and 3 months post-surgery-to determine whether earlier or later stimulation leads to greater symptom improvement. Participants will: * Undergo surgical implantation of an intracranial neurostimulation system targeting ALIC-NAc * Be randomly assigned to one of three DBS activation timing groups * Receive regular clinical assessments over a 6-month follow-up period after activation

NCT Number	NCT07031544
Lead Sponsor	Shanghai Mental Health Center Collaborators: Huashan Hospital, The First Affiliated Hospital of Shanxi Medical University, The First Affiliated Hospital of Nanchang University, Tianjin Anding Hospital, Tianjin Huanhu Hospital, The First Hospital of Hebei Medical University, First Affiliated Hospital of Jinan University, The Second Affiliated Hospital of Xinxiang Medical College, the Third Hospital of Mianyang
Conditions	Obsessive - Compulsive Disorder
Enrollment	60 participants
Start Date	2024-12-14
Primary Completion	2027-03-31 (estimated)
Study Completion	2027-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-07-03