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Amino Acid Infusion in Cardiac Surgery

StatusNot Yet Recruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Notable Primary completion pushed from Dec 1, 2026 to Oct 1, 2027
    • Start date: Mar 1, 2026 to Oct 1, 2026
    • Study completion pushed from Jan 1, 2027 to Nov 1, 2027
    v4
  2. Notable Start date: Nov 1, 2025 to Mar 1, 2026
    • Primary completion date: Jul 1, 2026 to Dec 1, 2026
    • Study completion date: Aug 1, 2026 to Jan 1, 2027
    v3
  3. Notable Start date: Aug 1, 2025 to Nov 1, 2025v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this study is to see if an infusion of amino acids given to adult male and female patients during cardiac surgery can help prevent acute kidney injury that commonly occurs when patients undergo cardiac surgery needing cardiopulmonary bypass. The main question the study aims to answer is if a short infusion of amino acids given to study participants during their scheduled heart surgery can decrease rates of acute kidney injury - which will be measured by biological markers of kidney injury in the urine. The study will be conducted in 2 phases. Participants in the first phase will receive the current standard of anesthetic care for patients having heart surgery and markers of acute kidney injury will be measured before and after their surgery. Participants in the second group will receive the anesthetic standard of care plus a short infusion of amino acids during their surgery. They will also have markers of kidney injury measured before and after their surgery. This study is based on prior studies that showed amino acid infusions are protective against kidney injury; however, these past studies did not look at markers of kidney injury in the urine.
Trial Details
NCT Number NCT07030933
Lead Sponsor Milton S. Hershey Medical Center
Conditions
(from sponsor)
Acute Kidney Injury, Cardiac Surgery
Related terms Acute Kidney Injury
Enrollment 130 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov