Early Discontinuation of Antibiotic Therapy in Elderly Patients Hospitalized for a Viral Infection

Among winter respiratory viruses, influenza is the most common and therefore responsible for the highest mortality, but parainfluenza and RSV viruses have an even higher risk of mortality (1.6 to 1.9 times), this toll being paid mainly by the elderly and co-morbid population. Futhermore, SARS-Cov2 will probably become endemic and/or epidemic with the same targets of fragile patients. These viral infections are serious, however a bacterial co-infection worsens the prognosis even more: excess risk of mortality = 2.6, 95% CI \[1.9-3.7\]. Although rare, these co-infections are the subject of a prescription of antibiotics in more than 50% of influenza infections or other serious viral infections. Mainly due to this excess risk of mortality associated with the difficulty of diagnosing these co-infections. Proper antibiotic use requires preventing this misuse and its harmful consequences in the short and long term at all costs. It is therefore imperative to have solid (grade A) evidence showing that antibiotic therapy in viral infections is not only futile but also potentially harmful.

NCT Number	NCT07030673
Lead Sponsor	Centre Hospitalier Universitaire, Amiens Collaborators: University Hospital, Rouen, Centre Hospitalier de Beauvais, University Hospital, Caen, Hôpital Les Bateliers, CHU de Lille, Centre Hospitalier Roubaix, CH SOISSONS, Tourcoing Hospital
Conditions	Elderly, Antibiotics Overuse, Viral Infections, PCR Multiplex
Enrollment	256 participants
Start Date	2025-02-14
Primary Completion	2027-03 (estimated)
Study Completion	2027-06 (estimated)
Updated on ClinicalTrials.gov	2026-01-16