The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.

NCT Number	NCT07030179
Lead Sponsor	Lanyue Zhu
Conditions	Postoperative Acute Kidney Injury, Frailty
Enrollment	1,000 participants
Start Date	2025-07-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-02