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Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy

Study acronym: PREG-Q10
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 20, 2026 (before its estimated June 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: May 15, 2026 to Jun 1, 2026
    • Study completion date: May 30, 2026 to Jun 10, 2026
    v5
  2. Primary completion date: Jan 15, 2026 to May 15, 2026
    • Study completion date: Jan 30, 2026 to May 30, 2026
    v4
  3. Trial status: Not Yet Recruiting to Recruiting
    • Site details revised
    v3
  4. Secondary endpoints: details revised at 8 of 8 entriesv2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This randomized controlled clinical trial aims to evaluate the effectiveness of adjunctive coenzyme Q10 and probiotic supplementation (Limosilactobacillus reuteri Prodentis®) in improving periodontal health in pregnant women undergoing non-surgical periodontal therapy. Forty participants will be randomly assigned to two groups: the test group will receive professional oral hygiene every three months along with a coenzyme Q10-based toothpaste and daily probiotic supplementation; the control group will follow the same protocol without probiotics. The primary outcome is the reduction of the Plaque Index (PI), while secondary outcomes include Bleeding on Probing (BoP), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), gingival inflammation (MGI, PMGI), plaque distribution (PCR%, API), and gingival recession (R). The study duration is 6 months. The goal is to assess whether this combined therapy can promote a balanced oral microbiota and enhance periodontal health during pregnancy.
Trial Details
NCT Number NCT07029360
Lead Sponsor University of Pavia
Conditions
(from sponsor)		 Pregnancy, Periodontal Disease, Gingivitis, Dental Plaque, Probiotics, Coenzyme Q10, Microbiota
Related terms Dental Plaque, Gingivitis, Periodontal Diseases
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov