Evaluation of Repeated Injectable PRF Following SRP in Patients With Periodontitis

The goal of this clinical trial is to learn if a treatment called injectable platelet-rich fibrin (i-PRF) helps improve gum health in people with a type of gum disease called Stage 3 Grade B periodontitis. The main questions this study aims to answer are: Does i-PRF help reduce gum inflammation and support healing? Are there changes in certain biological markers after using i-PRF? Researchers will compare two sides of the mouth. One side will receive i-PRF, and the other will be treated with salt water (saline) as a comparison. Participants will: Have a dental cleaning called scaling and root planing (SRP) Get i-PRF injected into deep gum pockets on one side of the mouth Have salt water placed in the other side's gum pockets Give gum fluid samples and have gum measurements taken at several visits (including 3 months later) Provide a small blood sample to prepare the i-PRF Researchers will collect and study gum fluid and look at markers related to healing and inflammation. The study will help find out if i-PRF is useful as a new treatment option for gum disease.

NCT Number	NCT07029035
Lead Sponsor	Saglik Bilimleri Universitesi Collaborators: Health Sciences University-Scientific Research Projects Unit
Conditions	Periodontitis Stage III
Enrollment	20 participants
Start Date	2023-12-01
Primary Completion	2024-12-01 (estimated)
Study Completion	2025-05-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-31