Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)

The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY). The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY. Many people with MODY report having gastrointestinal (GI) issues such as an upset stomach. Investigators also are interested in finding out if this drug will help with GI issues. If liraglutide does help with this symptom of MODY, the investigators want to know why this happens. If this drug is effective for participants, the investigators will use participants cells to make human induced pluripotent stem cell (iPSC). This means that the investigators will use participant cells to create what are called stem cells, which are cells in the body that are able to be told what their job is. Investigators will use these cells to see what happens in gastrointestinal (GI) tract.

NCT Number	NCT07029009
Lead Sponsor	Mansa
Conditions	Maturity Onset Diabetes of the Young
Enrollment	50 participants
Start Date	2025-05-08
Primary Completion	2026-08 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-17