Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity

The goal of this clinical trial will be to evaluate the effect applying an experimental gel based on cannabidiol oil (CBD) on tooth sensitivity induced by tooth bleaching with 35% hydrogen peroxide (HP). Volunteers will be selected and allocated to the following groups: GP - placebo gel, GCBD - experimental cannabidiol gel and GKF - Potassium Nitrate and Sodium Fluoride Gel. In each group, the corresponding desensitizing gel will be applied to on the teeth for 10 minutes. All groups will then undergo in-office whitening treatment with 35% hydrogen peroxide. Patients will be instructed to record tooth sensitivity on a daily basis during the 21 days of follow-up. Pain intensity will be measured using a visual analog scale (VAS), while the risk of developing sensitivity will be recorded after each session of the whitening procedure, with two response option.

NCT Number	NCT07027566
Lead Sponsor	Universidade Federal do Para
Conditions	Dentin Sensitivity
Enrollment	75 participants
Start Date	2025-07-25
Primary Completion	2026-05 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2025-06-18