Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery

The aim of this clinical trial is to evaluate the impact of the analgesic Oliceridine on postoperative nausea and vomiting (PONV) following gynecological laparoscopic surgery. It will also assess the safety profile of Oliceridine. The trial seeks to address the following key questions: Can Oliceridine reduce the incidence of postoperative nausea and vomiting (PONV) in gynecological laparoscopic surgery? Does the incidence of PONV differ between patients receiving Oliceridine and those receiving the commonly used analgesic sufentanil in gynecological laparoscopic surgery? Are there any opioid-related adverse reactions in gynecological laparoscopic surgery patients using Oliceridine? Participants will: Receive Oliceridine or sufentanil for anesthesia induction, maintenance, and postoperative pain management. Vital signs during surgery and the occurrence of postoperative nausea and vomiting will be recorded. Be followed up for at least 48 hours.

NCT Number	NCT07026162
Lead Sponsor	YanYing Xiao
Conditions	Gynecologic Surgical Procedures, Postoperative Nausea and Vomiting (PONV), Laparoscopy
Enrollment	96 participants
Start Date	2025-07-21
Primary Completion	2026-02-10 (estimated)
Study Completion	2026-02-25 (estimated)
Updated on ClinicalTrials.gov	2026-06-09