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Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation

Study acronym: RELEVANT
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 8 months later Dec 2028 → Sep 2029
See other at-risk trials from Technische Universität Dresden

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary and study completion pushed from Dec 2028 to Sep 2029
    • Recruitment opened
    • Start date changed from estimate of Sep 2025 to Jan 21, 2026
    • Trial sites expanded: 4 → 17 locations
    v4
  2. Start date: Jul 15, 2025 to Sep 2025v3
  3. Study title shortened, about 1 wordv2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation. The following will also be investigated: * Survival * Remission and Relapse rate * Engraftment or graft failure * Graft versus Host Disease (GvHD)
Trial Details
NCT Number NCT07025824
Lead Sponsor Technische Universität Dresden
Collaborators: medac GmbH
Conditions
(from sponsor)		 AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome)
Related terms Anemia, Refractory, with Excess of Blasts, Leukemia, Myeloid, Acute
Enrollment 220 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov