Clinical Trial

Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation

Study acronym: RELEVANT
Not Yet Recruiting Phase 2
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Summary
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation. The following will also be investigated: * Survival * Remission and Relapse rate * Engraftment or graft failure * Graft versus Host Disease (GvHD)
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-06-10; most recent amendment 2025-09-02.
Trial Details
NCT Number NCT07025824
Lead Sponsor Technische Universität Dresden
Collaborators: medac GmbH
Conditions AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome)
Enrollment 220 participants
Start Date 2025-09
Primary Completion 2028-12 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2025-09-03