Stellate Ganglion Morphine Infiltration on Myocardial I/R Injury

The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion (I/R) injury in AMI patients. It will also assess the safety of injecting morphine around the stellate ganglion via ultrasound guidance. The main questions it aims to answer are: 1\. Does morphine regulate stellate ganglion function to reduce myocardial I/R injury in AMI patients and improve one year outcome in AMI patients? 3. What medical problems do participants experience when receiving injected morphine around the stellate ganglion? Researchers will compare morphine to a placebo saline (as a control group) to determine whether stellate ganglion infiltration with morphine effectively treats patients with AMI following primary PCI. Participants will: * Receive a single injection of morphine or saline around the stellate ganglion. * Evaluate the myocardial injury during their duration of hospital stay. * Record their symptoms and any major adverse cardiovascular and cerebrovascular events within one year post-surgery.

NCT Number	NCT07023679
Lead Sponsor	The Second Hospital of Anhui Medical University
Conditions	Acute Myocardial Infarction (AMI)
Enrollment	2,588 participants
Start Date	2025-06-24
Primary Completion	2029-06-20 (estimated)
Study Completion	2029-06-20 (estimated)
Updated on ClinicalTrials.gov	2025-07-04