Clinical Trial

PENG Block Optimization: Volume and Dexamethasone Effects

Completed Phase 4
View on ClinicalTrials.gov →
Summary
This randomized controlled trial investigates the impact of local anesthetic volume and perineural dexamethasone on the analgesic and anti-inflammatory effectiveness of the pericapsular nerve group (PENG) block in patients undergoing total hip arthroplasty (THA). Patients were randomized to receive one of four PENG block variants differing in ropivacaine volume (10 mL or 20 mL of 0.2%) and the addition of 4 mg of perineural dexamethasone. The study evaluates postoperative pain, opioid requirements, systemic inflammatory markers, and quadriceps motor preservation.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-06-08; most recent amendment 2026-03-13.
Status change: Recruiting → Completed 2026-03-13
Status change: Not Yet Recruiting → Recruiting 2025-07-08
Trial Details
NCT Number NCT07023120
Lead Sponsor Poznan University of Medical Sciences
Conditions Hip Arthropathy, Hip Osteoarthritis, Hip Arthritis
Enrollment 120 participants
Start Date 2025-06-25
Primary Completion 2026-02-10 (estimated)
Study Completion 2026-02-20 (estimated)
Updated on ClinicalTrials.gov 2026-03-16