Lifestyle Intervention for Symptoms of Depression wIth App Support in General Practice

The goal of this clinical trial is to find out whether a smartphone app can help reduce symptoms of depression by supporting healthy lifestyle changes and encouraging self-monitoring in adults who visit their general practitioner with symptoms of depression. The main questions this study aims to answer are: Does a personalized lifestyle intervention delivered through the app, in addition to regular care, reduce depression symptoms more effectively than regular care alone? Is this approach more cost-effective than regular care alone? Researchers will compare patients who use the app alongside their regular care to patients who receive regular care without the app, to see whether the app leads to better outcomes. Participants who use the app will: Complete a lifestyle questionnaire focused on six themes: mental wellbeing, use of harmful substances, social relationships, healthy eating, sleep, and physical activity. Set personal goals based on their results and receive tailored lifestyle advice. Track their depression symptoms regularly within the app to support ongoing care. Have follow-up conversations with their general practitioner or mental health nurse to discuss their progress. Fill out questionnaires about their symptoms and experiences during the study.

NCT Number	NCT07022184
Lead Sponsor	Radboud University Medical Center Collaborators: Ixta Noa, Hogeschool van Arnhem en Nijmegen (HAN), Pro Persona Mental Health Care Foundation, Amsterdam UMC, Interactive Studios, University Medical Center Groningen
Conditions	Depressive/Anxiety Symptoms, Depressive Disorder
Enrollment	216 participants
Start Date	2025-06-17
Primary Completion	2026-11 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2025-12-22