Muscle Vibration as a Countermeasure Against Hypoactivity-induced

Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.

NCT Number	NCT07021079
Lead Sponsor	Centre Hospitalier Universitaire de Saint Etienne
Conditions	Vibration Therapy, Healthy Volunteer Study, Hypoactivity
Enrollment	42 participants
Start Date	2025-06-16
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-26