The Role of Skin Sodium Accumulation in Chronic Kidney Disease

This project consists of four substudies: a cohort study (A) and a sodium intake intervention (B) and a sodium excretion intervention (C) and a water intervention study (D). The main objective of the cohort study (A) is to investigate the prognostic implications of tissue sodium accumulation in CKD patients. The primary objective of the sodium intervention studies is to study the effect of high and low sodium intake (B) and increased renal sodium excretion (C) on tissue sodium content. The main objective of the water intervention study (D) is to investigate the effect of increased and habitual water intake on tissue sodium content and transepidermal water loss.

NCT Number	NCT07020104
Lead Sponsor	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Collaborators: Dutch Kidney Foundation
Conditions	Chronic Kidney Diseases
Enrollment	60 participants
Start Date	2025-01-07
Primary Completion	2039-12-01 (estimated)
Study Completion	2039-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-06-13