A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults

This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to characterize how varying BMI and fat topography influence regional ventilation and airway collapse in supine and prone positions. Healthy volunteers with a range of BMIs will undergo a 2-hour imaging session with noninvasive and minimally invasive monitoring.

NCT Number	NCT07019831
Lead Sponsor	Maurizio F. Cereda, MD Collaborators: National Institutes of Health (NIH)
Conditions	Healthy Volunteers Only
Enrollment	20 participants
Start Date	2028-01-01
Primary Completion	2029-12-31 (estimated)
Study Completion	2030-06-30 (estimated)
Updated on ClinicalTrials.gov	2025-06-18