Internet-based Mind-Body Training for Brain Health

The goal of this study is to conduct a Stage I pilot study examining the feasibility, acceptability, and preliminary effects of an internet-based, asynchronous mindfulness-based stress reduction program (iMBSR) compared to an internet-based, asynchronous lifestyle education program (iLifeEd), for adults at-risk for Alzheimer's disease (AD). Sixty middle-aged and older adults (aged 50 years or older) with subjective cognitive decline will be randomized to either an 8-week iMBSR program or an 8-week iLifeEd program control group, designed to provide adequate control for placebo effects. Behavioral, neuroimaging, and ecological momentary assessment (EMA) measures of mind-wandering will be administered to determine preliminary effects as a function of engagement in the iMBSR program. AD biomarkers will be examined at pre-training and post-training assessments.

NCT Number	NCT07019402
Lead Sponsor	Ohio State University Collaborators: National Institute on Aging (NIA)
Conditions	Subjective Cognitive Decline
Enrollment	60 participants
Start Date	2025-06-13
Primary Completion	2026-06-29 (estimated)
Study Completion	2026-07-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-27