Echocardiographic Parameters for Hemodynamic Support During CVVHDF

This prospective observational study aims to evaluate whether transthoracic echocardiographic parameters-Left Ventricular Outflow Tract Velocity-Time Integral (LVOT VTI), Mitral Annular Plane Systolic Excursion (MAPSE), Tricuspid Annular Plane Systolic Excursion (TAPSE), S' wave velocity, and E/e' ratio-can predict hemodynamic instability at the initiation of sustained low-efficiency daily dialysis (SVVHDF) in intensive care unit (ICU) patients. The study will include adult patients requiring SVVHDF, and echocardiographic measurements will be performed prior to dialysis. The primary outcome is the need for hemodynamic support (vasopressors/inotropes or fluid resuscitation) or development of hypotension within the first 60 minutes of dialysis. The study aims to identify which of these parameters best predict the need for hemodynamic intervention, with the goal of supporting individualized dialysis planning and safer fluid management in critically ill patients.

NCT Number	NCT07019051
Lead Sponsor	Kanuni Sultan Suleyman Training and Research Hospital
Conditions	Hemodialysis Complication
Enrollment	40 participants
Start Date	2025-06-23
Primary Completion	2026-01-13 (estimated)
Study Completion	2026-01-13 (estimated)
Updated on ClinicalTrials.gov	2026-01-15