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Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure

StatusNot Yet Recruiting
PhasePhase 3
Started2026-08
View on ClinicalTrials.gov ↗

Amendment history

2026-05-01
critical
Study Status v5
Primary completion pushed: 2027-08-01 → 2028-08-01
Completion pushed: 2027-09-01 → 2028-09-01
Start date2026-02→2026-08
2026-01-12
minor
Study Status, Oversight v4
Start date2025-12→2026-02
2025-10-17
minor
Study Status, Oversight v3
Start date2025-09-15→2025-12
2025-08-18
minor
Study Status v2
Start date2025-08-01→2025-09-15
2025-06-19
minor
Study Status, Study Description, Arms and Interventions, Outcome Measures v1
Secondary endpointsdetails revised at 1 of 3 entries
Study description+15 characters
[...] ing standardized protocols across two major health systems, wethe investigators will evaluate whether this novel approach can safely reduce [...]
2025-06-04
minor
Original filing
This will be a prospective, cluster-randomized, crossover, non-inferiority trial of 250 participants within 48 hours of an inpatient admission for heart failure or emergency department presentation for heart failure with plans for admission or observation/short-stay hospitalization comparing early discharge using subcutaneous furosemide to standard inpatient care. Individual practice groups will serve as "clusters" and the unit of randomization. Each participating cluster will implement either the early discharge strategy using the intervention or standard care for initial two-month blocks, followed by a crossover to the alternate strategy. The primary outcome is days alive and out of hospital at 30 days.
Trial Details
NCT Number NCT07018297
Lead Sponsor University of Texas Southwestern Medical Center
Conditions Heart Failure, Acute Decompensated Heart Failure
Enrollment 250 participants
Start Date 2026-08
Primary Completion 2028-08-01 (estimated)
Study Completion 2028-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-04