Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure

This will be a prospective, cluster-randomized, crossover, non-inferiority trial of 250 participants within 48 hours of an inpatient admission for heart failure or emergency department presentation for heart failure with plans for admission or observation/short-stay hospitalization comparing early discharge using subcutaneous furosemide to standard inpatient care. Individual practice groups will serve as "clusters" and the unit of randomization. Each participating cluster will implement either the early discharge strategy using the intervention or standard care for initial two-month blocks, followed by a crossover to the alternate strategy. The primary outcome is days alive and out of hospital at 30 days.

NCT Number	NCT07018297
Lead Sponsor	University of Texas Southwestern Medical Center
Conditions	Heart Failure, Acute Decompensated Heart Failure
Enrollment	250 participants
Start Date	2026-08
Primary Completion	2028-08-01 (estimated)
Study Completion	2028-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-04