Clinical Trial

Mood Effects of Serotonin Agonists: Depression

Study acronym: MESA-D
Completed Early Phase 1
View on ClinicalTrials.gov →
Summary
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-06-03; most recent amendment 2026-07-08.
Status change: Recruiting → Completed 2026-07-08
Status change: Not Yet Recruiting → Recruiting 2025-07-01
Trial Details
NCT Number NCT07017478
Lead Sponsor University of Chicago
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions LSD, Major Depressive Disorder, Depression
Enrollment 41 participants
Start Date 2025-06-09
Primary Completion 2026-06-01 (estimated)
Study Completion 2026-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-10