Clinical Trial

Low-Flow Desflurane vs Sevoflurane: Impact on Physiology and Recoveryand Recovery Profiles in Adult ENT Surgery

Study acronym: LoFADS
Completed
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Summary
This randomized, double-blind, controlled clinical trial aims to compare the effects of low-flow sevoflurane and desflurane anesthesia on physiological parameters and recovery profiles in adult patients undergoing ENT surgeries. The primary outcomes include heart rate, mean arterial pressure, peripheral oxygen saturation, end-tidal CO₂, and arterial blood gas values. Secondary outcomes involve time to spontaneous respiration, extubation, and response to verbal commands.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-06-10; most recent amendment 2026-02-25.
Status change: Recruiting → Completed 2026-02-25
Status change: Not Yet Recruiting → Recruiting 2025-06-12
Trial Details
NCT Number NCT07016308
Lead Sponsor Harran University
Conditions Anesthesia, General
Enrollment 40 participants
Start Date 2025-06-10
Primary Completion 2025-11-19 (estimated)
Study Completion 2025-12-15 (estimated)
Updated on ClinicalTrials.gov 2026-02-27