Retrospective Observational Evaluation of the Bone Mineral Density Outcome in Young Women With Amenorrhea

The study aims to evaluate the outcomes of different estrogen therapy regimens in patients with amenorrhea who face prolonged periods of hypoestrogenism. The primary objective is to compare the outcomes on bone mass of different therapeutic regimens and identify more favorable. For this purpose, densitometry parameters such as BMD, T-score and Z-score at the level of the lumbar spine, femur and entire skeleton will be considered, comparing a bone densitometry (DXA technique, Dual X-ray Absorptiometry) Baseline with one carried out after at least one year of therapy. The secondary objective of the study is to assess other systemic/metabolic implications of the different therapies.

NCT Number	NCT07015476
Lead Sponsor	IRCCS Azienda Ospedaliero-Universitaria di Bologna
Conditions	Amenorrhea
Enrollment	180 participants
Start Date	2020-11-09
Primary Completion	2025-10 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2025-06-11