The Combined First Trimester Screening

The project is a national, prospective, multicenter pilot project. The project is focus on setting up the combined first trimester screening in the Czech Republic. The combined first trimester screening is aimed at predicting and detecting the most serious obstetric complications, such as the great obstetrical syndromes (preeclampsia, fetal growth restriction, preterm labor and intrauterine fetal demise "IUFD") and structural congenital defects (morphological and chromosomal). The primary objective of the project is to create a unified methodology for performing and evaluating the combined first trimester screening in connection with the National Health Information System (hereinafter referred to as "NHIS"), which will enable recording, providing analysis and linking recorded clinical parameters with data in the NHIS. The pilot project will also provide data for modeling appropriate mechanisms for reimbursement from public health insurance.

NCT Number	NCT07015203
Lead Sponsor	Institute of Health Information and Statistics of the Czech Republic Collaborators: University Hospital Olomouc, Institute for the Care of Mother and Child, Prague, Czech Republic, Krajská zdravotní, a.s. - Nemocnice Most, o.z.
Conditions	Preeclampsia (PE), Fetal Growth Restriction, Congenital Abnormalities, Preterm Labor, Intrauterine Fetal Demise, Genetics Syndrome, Pregnancy Overdue - Week 41+6
Enrollment	2,000 participants
Start Date	2025-06-15
Primary Completion	2026-10-31 (estimated)
Study Completion	2027-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-17