Feasibility Test of Folic Acid on Acute Kidney Injury

The goal of this clinical trial is to evaluate the feasibility of folic acid supplementation as a treatment for adult patients with acute kidney injury (AKI) receiving hospital care. The main question it aims to answer is: Is it feasible to conduct a fully-powered randomized controlled trial (RCT) to assess the efficacy and safety of folic acid supplementation in AKI management? Researchers will compare two groups (usual care vs. usual care + 5 mg folic acid) to determine the feasibility of folic acid supplementation and estimate the sample size required for a fully powered RCT. Participants will: 1. Receive either usual care, or usual care combined with oral folic acid (5 mg daily) until AKI resolution (up to 30 days); 2. Undergo regular monitoring during hospitalization and follow-ups at 3 months and one year post-discharge.

NCT Number	NCT07013136
Lead Sponsor	The University of Hong Kong Collaborators: Queen Mary Hospital, Hong Kong
Conditions	Acute Kidney Injury
Enrollment	90 participants
Start Date	2025-10-01
Primary Completion	2027-03-31 (estimated)
Study Completion	2027-09-30 (estimated)
Updated on ClinicalTrials.gov	2025-07-15