Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis

This study looks at memory problems after surgery in people with liver disease. We want to know how often these problems happen and what might cause them. The main question it aims to answer is: 1. Do people with liver disease have more memory problems after stomach surgery than people without liver disease? If yes, how much more often? 2. Are changes in stomach bacteria and body chemicals related to these memory problems? Who can join: * Adults getting stomach surgery * Both people with and without liver disease What participants will do: * Take memory tests before and after surgery * Give stool (poop) and blood samples before and after surgery Why this matters: Memory problems after surgery can make recovery harder. If we find that stomach bacteria or body chemicals are involved, doctors might find new ways to prevent these problems in people with liver disease.

NCT Number	NCT07012434
Lead Sponsor	Sichuan Provincial People's Hospital
Conditions	Liver Cirrhosis
Enrollment	133 participants
Start Date	2025-06-15
Primary Completion	2025-09-01 (estimated)
Study Completion	2025-10-30 (estimated)
Updated on ClinicalTrials.gov	2025-06-10