The FACIAL Study Pilot

Facial recognition is a non-invasive method for analysing facial characteristics and changes in facial expressions. There is evidence to suggest there may be a link between physiological health and facial expression patterns. Many medical conditions are associated with specific facial characteristics, with some related to inherited genetic conditions and others that have been acquired as a result of medical conditions such as stroke, nerve injuries and dementia. If successful, this technology could prove useful for studies evaluating the monitoring of acute or chronic illness. The proposed study will ask participants to do a maximal exercise test that will challenge the body, as a proof-of-principle, to see how this correlates with facial expressions. Depending on the study outcomes and future work, it could prove to be a useful tool and clinical application in healthcare for evaluating and tracking patient health and well-being. The investigators want to conduct a proof-of-principle study where physically stressed young and healthy participants (in the form of a maximal exercise test), whilst recording facial expressions, will be used to determine the relationship between physiological stress and changes in facial parameters.

NCT Number	NCT07011407
Lead Sponsor	Lancaster University Collaborators: University of Central Lancashire, East Lancashire Hospitals NHS Trust
Conditions	Healthy Adult
Enrollment	15 participants
Start Date	2025-06-01
Primary Completion	2025-08-12 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-06-08