Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery

Beyond its established use as a bronchodilator and therapy for apnea of prematurity, aminophylline has demonstrated utility in reversing the effects of anesthetics, enhancing recovery by accelerating respiratory and cognitive functions. Variations in dosage (1-6 mg/kg) have been explored, but questions persist regarding optimal timing and dosing for pediatric surgical populations to achieve maximal efficacy with minimal adverse effects. This randomized controlled study aims to evaluate the effect of early versus late aminophylline administration on recovery profiles in pediatric patients undergoing ambulatory surgery under sevoflurane anesthesia. Sixty children aged 4-12 years will be randomly allocated into three groups: Group (E) will receive aminophylline early intraoperatively, Group (L) will receive aminophylline late intraoperatively, and Group (C) will receive normal saline post-anesthetic discontinuation.

NCT Number	NCT07011134
Lead Sponsor	Hany Mohammed El-Hadi Shoukat Mohammed
Conditions	Postoperative Recovery, Pediatric Anesthesia, Ambulatory Surgery
Enrollment	60 participants
Start Date	2025-06-15
Primary Completion	2025-08-15 (estimated)
Study Completion	2025-08-15 (estimated)
Updated on ClinicalTrials.gov	2026-06-16