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Biomarkers of the Locus Coeruleus Nucleus: Links With Early Tau Pathology, Cognition and Alzheimer's Disease Risk

Study acronym: Locus-Tau
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Jan 1, 2026 to Feb 2, 2026 · Eligibility criteria expanded, about 21 words · Secondary endpoints revised (16) · 1 morev3 Show 4 more changesShow less
    • Start date changed from estimate of Jan 1, 2026 to Feb 2, 2026
    • Eligibility criteria expanded, about 21 words
    • Secondary endpoints revised (16)
    • Site details revised

    See this version in full on ClinicalTrials.gov ↗

  2. Start date: Jun 1, 2025 to Jan 1, 2026v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Alzheimer's disease (AD) is characterized by a long-lasting silent phase. Among initial events, emergence of tau pathology in locus coeruleus (LC) brainstem nucleus, well before the one observed in medial temporal cortex, is highly relevant. LC integrity and function can be assessed in vivo with MRI and pupil measures. The current research proposes to evaluate these LC markers in an aged healthy cohort (n=100, with half APOE4 positive) and to relate these markers with cerebral tau pathology, AD risk and cognitive function.
Trial Details
NCT Number NCT07007208
Lead Sponsor University Hospital, Toulouse
Conditions Alzheimer Disease
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov