Clinical Trial

PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

Name: PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma — clinical trial record (NCT07007117)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: PHOX2B

Active, Not Recruiting Phase 1

View on ClinicalTrials.gov →

Summary

This is a first in human dose escalation trial to determine the safety of administering PHOX2B PC-CAR T cells in patients with advanced, high-risk neuroblastoma.

Protocol Amendment History 1 change

critical Trial status changed: Recruiting → Active, Not Recruiting 2026-07-02

Trial Details

NCT Number	NCT07007117
Lead Sponsor	Stephan Grupp MD PhD Collaborators: Children's Hospital of Philadelphia, Alliance for Cancer Gene Therapy, Children's Cancer Research Fund
Conditions	Refractory Neuroblastoma, Relapsed Neuroblastoma, High-Risk Neuroblastoma
Enrollment	38 participants
Start Date	2025-06-20
Primary Completion	2032-06-30 (estimated)
Study Completion	2035-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-01