Interventional Ablation for Early-stage Lung Cancer

What is this study about? This clinical trial aims to compare two treatments for high-risk lung nodules or early-stage lung cancer: interventional ablation (a minimally invasive procedure that destroys tumors with heat or cold) and surgical resection (surgery to remove the tumor). The goal is to determine if ablation is as safe and effective as surgery while preserving more lung function. Why is this important? Lung cancer is a leading cause of cancer deaths worldwide. Early detection improves survival, but surgery can damage lung function. Ablation (e.g., microwave, cryotherapy) is less invasive than surgery and may offer similar outcomes with faster recovery. However, more evidence is needed to confirm its role in early-stage disease.

NCT Number	NCT07005999
Lead Sponsor	Guangzhou Institute of Respiratory Disease Collaborators: Hunan Provincial People's Hospital, Beijing Chao Yang Hospital, Fuda Cancer Hospital, Guangzhou, University of South China Affiliated Nanhua Hospital, Nanfang Hospital, Southern Medical University, The First Affiliated Hospital of Guangzhou Medical University, Sir Run Run Shaw Hospital, Eastern Theater General Hospital,QinHuai District Medical Area, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Emergency General Hospital, The First Affiliated Hospital of Anhui Medical University, The Second Hospital of Anhui Medical University, Huaxi Hospital, Shanghai Chest Hospital, Military 301 Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions	Lung Cancer (NSCLC), Early Stage Lung Non-Small Cell Carcinoma
Enrollment	656 participants
Start Date	2025-04-12
Primary Completion	2028-12-21 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-06-05