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Optimising TREATment for Severe Gram-Negative Bacterial Infections

Study acronym: TREAT-GNB
StatusRecruiting
PhasePhase 4
Started2025-04-21
View on ClinicalTrials.gov ↗
TREAT-GNB is an innovative trial to expedite the evaluation of various antibiotic choices and treatment strategies for severe multidrug-resistant Gram-negative bacterial infections, specifically bloodstream and lower respiratory tract infections. This approach combines platform trial elements with adaptive clinical designs to streamline the evaluation of various treatment options and optimise resource utilisation. The overall aim of the TREAT-GNB platform trial is to identify interventions that improve survival in patients with severe infections due to Gram-negative bacteria. In the CR-GNB silo of TREAT-GNB, the primary objective is to quantify the effect on all-cause mortality at 28 days of a range of interventions in patients with bloodstream infections, ventilator-associated pneumonia, and hospital-acquired pneumonia caused by CR-GNB.
Trial Details
NCT Number NCT07004049
Lead Sponsor National University of Singapore
Collaborators: The University of Queensland, European Clinical Research Alliance for Infectious Diseases (ECRAID)
Conditions Bloodstream Infection, Ventilator Associated Bacterial Pneumonia, Hospital Acquired Bacterial Pneumonia, Carbapenem Resistant Bacterial Infection, Multidrug Resistance
Enrollment 600 participants
Start Date 2025-04-21
Primary Completion 2028-12-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-06-04