Neural Control and Mechanosensation in Spine Muscle

Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization. Lumbar spine muscle is compromised in LBP, and do, and do not, respond to exercise based physical therapy program depending on measurements representing activation capacity of lumbar muscle. Here, we will characterize the neurological and muscle specific features that may contribute to limited activation in an attempt to identify sources of resistance to recovery in patients with chronic disc injury and identify precision rehabilitation approaches for this complex population of individuals.

NCT Number	NCT07003802
Lead Sponsor	University of California, San Diego
Conditions	Low Back Pain and Core Muscle, Disc Herniation
Enrollment	152 participants
Start Date	2025-07-01
Primary Completion	2029-05-01 (estimated)
Study Completion	2030-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-01