Clinical Trial

PULSE PVC Registry: Multicenter Study on Focal Pulsed Field Ablation for Premature Ventricular Contractions

Enrolling by Invitation
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Record status
This record was last updated June 10, 2025 (before its estimated December 1, 2025 completion). Its status may not reflect the trial's current state.
Summary
The PULSE PVC Registry is a European multicenter observational study designed to assess the safety and efficacy of focal pulsed field ablation (PFA) using the Centauri Generator system in patients with symptomatic premature ventricular contractions (PVCs). The registry collects standardized procedural and follow-up data across diverse PVC origins, enabling comparisons with historical radiofrequency (RF) ablation outcomes. Data will include baseline characteristics, procedural details, complications, and long-term PVC burden reduction. Each center will obtain local ethics approval, and only anonymized data will be analyzed.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-05-25.
Trial Details
NCT Number NCT07003412
Lead Sponsor Zentralklinik Bad Berka
Conditions Premature Ventricular Contraction (PVC), Pulsed Field Ablation
Enrollment 200 participants
Start Date 2024-06-01
Primary Completion 2025-12-01 (estimated)
Study Completion 2026-04-01 (estimated)
Updated on ClinicalTrials.gov 2025-06-10